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J Thorac Cardiovasc Surg 154(2):568-569, 2017

[43] reported that formation of high levels of superoxide radical by H.pylori will increase the activity of SOD in gastric mucosa

Unlike other cell death modalities, paraptosis lacks the typical apoptotic hallmarks, such as DNA condensation, DNA breakage, membrane blistering, and apoptotic bodies

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For example, the dual effect of sericin on osteoblasts and osteoclasts has been shown in rodents [9], but clinical studies are needed to confirm the efficacy and safety of sericin as an osteoporosis or bone-healing treatment in humans

Additionally, its higher levels were associated with metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), cancer, and pulmonary arterial hypertension (PAH), but with more controversy (80, 84)