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Flavonoids present a multi-targeted therapeutic approach that not only inhibits viral invasion and replication but also regulates the hosts inflammatory response, thereby offering therapeutic benefits (286, 287)

Serial vaccination Rather than trying to present multiple antigens together in the form of a mosaic vaccine to the immune system, an alternative approach could be to sequentially vaccinate with different antigens in a series in an attempt to boost the most cross-reactive immunity (Fig

Evidence for gut microbiota involvement in anxiety disorders is consistent across human studies and strongly supported by preclinical mechanistic data, with therapeutic interventions showing early promise in randomized controlled trials, yet still requiring a large-scale validation

doi: 10.1038/s41586-019-0931-y 9 BamM.YangX.BusbeeB

However, specific studies on the roles of these key molecules at different stages of DOR progression are still lacking

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