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Daratumumab (Janssen Pharmaceuticals) is the first high-affinity CD38-targeting Ab to be approved by the FDA and EMA as a monotherapy for relapsed/refractory MM (RRMM) [65]

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In summary, the fact that NNMT plays a role in a number of diseases/conditions makes development of NNMT inhibitors an important path to developing therapeutics to treat various diseases/conditions

In our case study as well as these published combination therapies, anti-CD38 was given prior to the application of the PD1-based ICI

Impatience and inconsistency Skipping doses, bouncing between strategies, or giving up early guarantees failure