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In the PCOS ovarian microenvironment, key functional cells such as granulosa cells are particularly vulnerable to this pathway, which directly impairs follicular development and maturation

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46 48 Conversely, topiramate may cause substantial cognitive impairment, particularly when used at high doses or during rapid dose escalation

Wang et al., 2015), they demonstrate competitive-like kinetic behavior with both sphinganine and stearoyl-CoA, in cell culture (Merrill et al., 1993)

In addition to this, similar positive effects on the general brain function of older people who did not have Alzheimer's or other brain diseases could be found