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When estrogen levels drop, cells become more resistant to insulin's signals

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The significance of differences in protein abundance was determined with a Paired T-test for sibling cohort comparisons and a T-test for comparisons of unrelated groups such as Stage 1 versus Stage 3

Images were collected using a CFI Plan Apochromat Lambda D oil immersion objective (60, NA = 1.4) and for roGFP imaging a CFI Plan Apo VC water immersion objective (60, NA = 1.2)

A key feature is its flexible loop 2, which may serve a gating function for substrate binding specificity

Discusses nutrients and foods that support hepatic detoxification (sulfur-rich vegetables, flavonoids, glutathione precursors)