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Liver Effects: In HIV-associated NAFLD, tesamorelin reduces liver fat and attenuates fibrosis progression, supported by transcriptomic downregulation of fibrotic and inflammatory gene pathways

The Ontario Drug Benefit (ODB) database was used to identify patients who were prescribed vitamin B12 injections, and the Ontario Health Insurance Plan database was used to identify all physician claims for intramuscular injections as well as laboratory tests assessing vitamin B12 levels

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Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis