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The human leukocyte antigen ( HLA-Cw6 ) is considered one of the strongest alleles determining the development of this disease (199, 207)

SB wrote the first draft of the manuscript

Alternatively, it is plausible that an initial T cell-independent response is triggered by the exposed, repeating Fc domains on the outside of the immune complex, consistent with our observation that the early antibody response is largely Fc-specific

Its safety profile has been well-established in clinical trials, with no significant adverse effects reported

A clinical study has shown that cream with niacinamide enhances skin barrier function before application of 0.025% Vitamin A and significantly reduces the skin irritation such as dryness or peeling, burning, and stinging

Moreover, SAT1 has been demonstrated as an inducer of arachidonate 15-lipoxygenase (ALOX15) expression, a key enzyme involved in lipid peroxidation of PUFAs, especially the arachidonic acid [47]