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Okun and colleagues drew attention to this phenomenon in a series of four patients who developed dystonia after weeks of cast immobilization [ 43 ]

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Studies indicate that disruptions in the composition and quantity of gut microorganisms are associated with immune dysfunction, protein misfolding in the brain, inflammation, and altered neuronal and synaptic development

Oxidative protein folding typically occurs in dedicated subcellular compartments, particularly the periplasmic space of Gram-negative bacteria and the endoplasmic reticulum (ER) in eukaryotic cells

doi: 10.3892/ijo.2017.4134 167 ShaoLZhuLSuRYangCGaoXXuYet al

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