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LCMS metabolite quantification in HeLa cells A total of 1 10 6 treated HeLa cells or 1 10 6 Cas9-expressing HeLa cells were collected, washed with cold PBS and metabolic activity quenched by freezing samples in dry ice and ethanol, and stored at 80 C

Mild swelling or redness at the injection site

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The accelerated heart rate and blood flow induce an increase in vascular shear stress, which further activates eNOS activity and promotes NO production from vascular endothelial cells

In-depth study into the molecular mechanisms underlying ferroptosis and regulators of ferroptosis significantly enhances our understanding of the pathologies of kidney diseases

Moreover, we emphasize GSH system-related ferroptosis in cardiac injury events and comprehensively summarize strategies for GSH system activation