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When tested in vitro with TCA enzymes, ATP inhibits citrate synthase and -ketoglutarate dehydrogenase

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Therefore, KRAS-driven cancer cells are sensitive to radiotherapy during glutamine deprivation (106)

ReceptorLigand Binding Assays The peptide serves as a selective ligand in receptor binding studies to evaluate GHSR-1a affinity, receptor density, and activation thresholds under controlled assay conditions

These same electrophilic interactions activate host Nrf2 signaling via Keap1 modification, linking antimicrobial and immunomodulatory effects (Unoki et al., 2020)

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