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The hydrophobic residue of the peptide is embedded in the hydrophobic pocket, which enhances the binding stability by van der Waals force and prevents the substrate from sliding into the active cavity (Hu et al., 2022b)

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By PASS prediction 4-NP shows hematotoxicity 12 in vivo studies, other toxicity such as nephrotoxicity, and acetylcholine inhibitor

doi:10.1186/s12931-019-1187-7 57

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The antibody recruits other defensive molecules and immune cells, like T-cells in the bloodstream, to make their way to the now marked invader