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Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

The inactivation of this protein leads to the inhibition (stopping) of neurotransmitter and neuropeptide release from the nerve endings and the prevention of the electrical pain signals from firing off

Tardelli, M

doi: 10.1186/1475-2891-12-37 17

youll be telling yourself that eating a lot of animal protein late at night before you sleep is just asking for it (unless you sleep standing up)