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This results in activated T cells & B cells that produce an anti-citrulline inflammatory response that affects the joints, resulting in swelling and degradation of both cartilage and bone (Schur & Firestein, 2012) as illustrated in Figures 3, 4 & 5

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The Bioconductor package DESeq2 v1.36.0 (Love, Huber, and Anders 2014) was used to test for differential gene expression between the experimental groups

Antioxidants can slow the progression of these disorders by modulating microglial function and activity

Mendelian randomization supports dyslipidemia as an independent glaucoma predictor [103], where HDL-C inversely correlates with risk [104] while LDL-C [105] and TG show positive associations [106]

1,2,6,12 Dementia-like disease, including episodes of psychosis, is thought to be associated with more severe and chronic deficiency, although supporting evidence is poor