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However, the disease remains a problem worldwide and causes tens of thousands Trusted Source of deaths annually, mostly in rural areas of Southeast Asia and Africa

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Its also worth noting that niac a form of vitamin B3 has separately been studied for its effects on skin pigmentation and barrier function, though its relationship to periorbital hyperpigmentation specifically is still emerging

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Of the 50 subjects who survived, 9 subjects (18%) had neurological sequelae at hospital discharge