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identified a novel senescence-associated miRNA, miR-146a, which negatively regulates the NAD/SIRT pathway by directly targeting NAMPT, while AMPK activators such as metformin counteract this process by suppressing miR-146a expression through the IKK/NF-B axis, thereby restoring NAD production and offering a new therapeutic strategy against aging

Overall, the consistent finding of elevated lipid peroxidation markers across various studies and sample types provides robust evidence of heightened oxidative stress in CF, contributing to cellular dysfunction and disease progression

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

Mater 6 (11), 38653878

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