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555,556 Lifestyle modifications include head-up tilt sleeping, which elevates the head of the bed by 1030 to reduce nocturnal diuresis and improve morning orthostatic tolerance, and advising patients to avoid triggers such as prolonged standing, sudden postural changes, high ambient temperatures, and large meals that may exacerbate symptoms

Semaglutide (Wegovy) for the treatment of obesity or weight management should not be used during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm due to the potential hazard of maternal weight loss to the fetus

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They target distinct biological pathways, which is precisely why their combination (CagriSema) is under investigation offering broader metabolic coverage than either agent individually