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165 Interestingly, the 5 promoter region of the human CD38 gene contains binding sites for several cytokines, such as TNF, NF-IL6, IL13, and IL4

Ma et al., 2017

Mechanistically, glutamine is a major precursor for glutathione synthesis, therefore, limiting the utilization of glutamine by tumor cells leads to the reduction in GSH, inhibits the activity of sarcoplasmic reticulum Ca 2+ -ATPase (SERCA), and activates the NF-B signaling pathway, thereby promoting the expression of tumor PD-L1 and inactivating the co-cultured T cells

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[Link] Beelman R.B., Phillips A.T., Richie J.P., Ba D.M., Duiker S.W

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