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Dendritic cells normally participate in antigen presentation, cytokine production and immune cell recruitment

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The optimised formulation had a zeta potential of -0.1mV (Figure 2)

Related studies show that nociceptortumor interactions impair antitumor immunity and alter neurite outgrowth and mediator release, consistent with a feed-forward loop in which neurotrophin-dependent axonogenesis and neuronal activity reinforce immune suppression (6062)

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However, inorganic sonosensitizers easily undergo electron-hole recombination pairs under US stimuli, which greatly limits ROS production and extremely reduces the therapeutic effect of SDT