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doi: 10.1016/j.ophtha.2013.04.030 20 HeemrazBSLeeCNHysiPGJonesCAHammondCJMahrooOA

452 Targeted drug delivery Targeted drug delivery is a strategic approach in drug administration that aims to deliver therapeutic agents precisely to specific tissues or sites, thereby enhancing therapeutic efficacy while minimizing adverse reactions

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The blocks of mineralized cartilage resulting from impaired resorption of osteoclasts are extensive and further project into the metaphyseal marrow cavity in contrast to normal bones [24]

The protective role of selenium metabolism is thought to be exerted through the neutralization of ROS via antioxidant activities of selenoproteins including GPXs and TXNRDs