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The current recommended therapeutic approach 3,4,6,7,9 for managing severe symptomatic chronic hyponatremia emphasizes timely intervention with intravenous hypertonic saline to achieve a targeted rise in serum sodium levels, aiming for an increment of 46 mmol/L within the first 24 h

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In contrast, differentiated Th1 and Treg cells treated with IGF-1 did not show any change in IFN- or Foxp3 expression, respectively, nor increased cellular metabolism (Supplementary Fig

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