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For a useful extension of the "cytoprotective" effect into an "organo-protective" effect the investigation of endothelium protection is generally accepted

Bottom line: MTHFR doesnt cause these conditions it can, however, tilt the terrain and thats actionable when we combine genetics with labs and clinical context

Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia

If youre unsure, consider rotating between the abdomen and thigh to see which feels more comfortable and provides better results

doi:10.3389/fphar.2021.627533 Liu C, Yu Z, Huang F, et al