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The Broader Context of Wellness It is important to remember that supplements are just one piece of the puzzle

SAM acts as the bodys main methyl donor , fueling DNA, RNA, and protein methylation

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Although conceptually distinct, in practice, many biomarkers used in trials perform both roles simultaneously

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On the other hand, beneficial metabolites such as butyrate can activate cellular mechanisms for protein clearance: butyrate readily crosses the BBB and can inhibit histone deacetylases, thereby activating gene expression programs that enhance autophagy and reduce toxic protein aggregates [55]