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Clinical Applications

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Tchkonia, J.L

Intensity of behavioral disturbances and seizure presentation assessment After paracetamol application, intensity of progressing behavioral disturbances and seizure presentation was continuously monitored, and assessed and scored (score 0 - normal, score 1 - rearing on hind legs, shaking, 2 - sleepy, tottering walk, 3 - sleepy, tottering walk and repeatedly falling down, 4 - sleepy, tottering walk and repeatedly falling down, jerking of the extremities, 5 - lying down, generalized convulsions) at particular time points depending on the regimen used, as described before

CJC-1295 without DAC (also called Modified GRF 1-29) has a half-life of approximately 30 minutes, while CJC-1295 with DAC binds to serum albumin via a maleimide linker and extends the half-life to roughly 68 days, allowing weekly rather than daily dosing in research models