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doi: 10.1371/journal.pone.0130322 148 FernandoRSmithTJ

Usually that means that the spacer is devoid of charge so that it doesnt interact with proteins through a charge-based mechanism like what is intentionally used in ion exchange chromatography

Diagnostic evaluation Recommendations and Suggestions R1.1 We recommend always assessing testicular position at birth in all newborns and at 3 and 6 months of age in those with congenital cryptorchidism, for the known possibility of spontaneous descent within the first 6 months of life (1, )