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10.1385/BTER:89:1:85 Biol

But as evidence propositions they are worlds apart: one is an FDA-approved drug with replicated Phase 3 trials, the other is an unapproved research chemical with two small surrogate-marker studies and discontinued development

One has the patents on the water they use

J.SimrenM.et al

Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen tablets-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions