glutathione dehydrogenase 1 Overview of glutathione-dependent formaldehyde metabolism. (A) Summary Emerging strategies for enhanced glutathione

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When GPX4 activity is lost, or its substrate GSH becomes increasingly depleted, ferroptosis progresses more rapidly

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However, in advanced HCC stages, where tumor cells have metastasized, therapeutic approaches often aim to increase ROS levels to induce tumor cell death

These findings were corroborated in the work presented by Song et al., who showed that ovarian cancer could induce endoplasmic reticulum stress in cytotoxic T cells, which depleted glutamine transporters in these cells and subsequently led to T-cell dysfunction [152]

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