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For this reason, smaller organoid systems may be preferred at the expense of low cellular diversity, loss of long-range connectivity, and electrophysiological properties that do not fully recapitulate disease states [225, 226]

Experimental evidence from diverse cell models indicates that CA IX acts here primarily via its catalytic activity and pH regulating function, which helps to maintain slightly alkaline intracellular pH that is critical for survival, metabolic performance, and proliferation of cancer cells, particularly in hypoxic conditions

Modulation of the gene expression of annulus fibrosus-derived stem cells using poly(ether carbonate urethane)urea scaffolds of tunable elasticity

Circulation 137 , 11431157 (2018)

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Studies show that PD risk genes such as GBA, LRRK2, and PARK2 are also linked to lipid metabolism [82]