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Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Joshi S, Singh AR, Durden DL

doi: 10.3390/bioengineering6040113 20 CleversH

ROS generated by the Fenton reaction tends to react with phospholipids (PL) to form hydroperoxy-phospholipids (PLOOH), which are the main elimination target of GPX4 (Wiktorowska-Owczarek et al., 2015)

ALA primarily acts as a multifunctional redox modulator and mitochondrial cofactor, UA promotes mitochondrial quality control through mitophagy and mitochondrial biogenesis, and EGT functions as a stable cytoprotective antioxidant with selective cellular uptake

This distal ROS spread correlated with rapid trafficking of oxidized mitochondria toward distal regions of the cell (Supplementary Movie 3), but mitochondrial motility across the cell was rarely visualized ( ~ 13% of total photostimulations) in our experimental timescale