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72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy

Eighteen years later, FDAs briefing document for its December 2024 advisory committee meeting put the same event into the regulatory record with more clinical detail

After the treatment, the mice were sacrificed, the tumor tissues were obtained and analyzed (photographs of the tumor: Supplementary Fig

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, et al