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Guerrero et al

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have demonstrated that HIF-1 directly binds the MDR1 promoter and promotes MDR1 expression, as confirmed with ChIP assays 41

& Luo, X

It stimulates lipolysis (breakdown of stored fats) and inhibits lipogenesis (formation of new fat), primarily via activation of -adrenergic and AMP-activated protein kinase (AMPK) pathways