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Among other effects, polyphenols can block iron uptake, inhibit digestive enzymes, alter intestinal microbiota, and hormonal balance, and interact with different drugs [601], which may lead to undesired adverse effects in these patients

2.1.3.3 Immune cell exhaustion and energy failure: T-lymphocytes (especially CD4 + and CD8 + T cells) are highly sensitive to metabolic perturbations

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS