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R6.7 We recommend determining pubertal status before any treatment (1, )

Bonnet AM, Jutras MF, Czernecki V et al (2012) Nonmotor symptoms in Parkinsons disease in 2012: relevant clinical aspects

doi: 10.1016/j.neurobiolaging.2006.03.008

The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism

metformin) are also at increased risk of deficiency

Clinical studies suggest that consistent daily supplementation for 48 weeks is typically needed before any improvement becomes apparent