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Mitochondria, which help cells produce energy, can also be affected

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With the increased emotional and physical stress, it is believed that the majority of the population has a degree of mitochondrial impairment that causes a cascading effect of inflammation and disease development

To prevent medication overuse headache, migraine patients should (on average) limit use of NSAIDs to 15 or fewer days a month and limit triptan or over-the-counter combination analgesic use to 9 or fewer days a month (Garza 2012

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