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While GLP-1 acts through modulation of NF-B signaling, reduction of oxidative stress, and enhancement of chondrocyte survival and autophagy, 5-ASA similarly downregulates inflammatory mediators (IL-6, COX-2, IL-8) and promotes anabolic responses, including increased proteoglycan synthesis and ECM preservation

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Krantz MS, Stone CA, Abreo A, Phillips E (2020) Oral challenge with trimethoprim-sulfamethoxazole in patients with sulfa antibiotic allergy