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Factors that can increase the risk of developing epidural or spinal hematomas in these patients include: use of indwelling epidural catheters concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, or other anticoagulants a history of traumatic or repeated epidural or spinal puncture a history of spinal deformity or spinal surgery Monitor patients frequently for signs and symptoms of neurologic impairment

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Secondly, N-induced biochemical defence represents a network of phytoalexins, antimicrobial proteins, defence-related enzymes, amino acid and organic acid metabolism, and endogenous hormones