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Dysfunction of organelles such as mitochondria and endoplasmic reticulum is also an object of autophagy regulation of cellular ferroptosis

The evidence for this is mainly based on the observed significant antiallodynic and antihyperalgesic effects of GAT-1 inhibitors in rodent models of CIPN

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The NLR is an emerging marker of systemic inflammation that has been associated with disease activity in RA 24,25