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Description

Integrative proteomic and transcriptomic analysis identifies TrkB (NTRK2) as a therapeutic target and a potential driver of EGFR inhibitor resistance in lung squamous cell cancer

Hess B, Bekker H, Berendsen HJC, Fraaije JGEM

Danchin A (2018) Bacteria in the ageing gut: did the taming of fire promote a long human lifespan

As expected, Stattic and TRi-1 converted TGR to a pro-oxidant enzyme, whereas our non-covalent inhibitors did not increase NADPH consumption or superoxide production (Fig