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Meanwhile, hypoxia can promote proliferation of NPSCs, which may be related to the HIF-1 signal transduction pathway mediated by SIRT1 and SIRT6

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Additionally, the APOL1 gene may interact with other genes to cause kidney disease

81,143,144,145 Even though the overexpression of enzymes involved in both the synthesis and breakdown of H 2 S has thus far only been reported for colorectal cancer, 134 it can be envisaged that overexpression of both enzymatic pathways might be a common trait for any cancer type where H 2 S production is increased, as excess H 2 S can become toxic even for the most robust cancer cells (see below)

The pH of each sample was adjusted within the range of 7 to 9 using 014 pH strips (#13640516, Thermo Fisher Scientific) before subjecting them to digestion with mass spectrometry-graded trypsin (#90057, Thermo Fisher Scientific) at a 1:20 trypsin to protein (w/w) ratio

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