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The data indicate that bacterial metabolites entering the circulation can substantially alter the host metabolisms via interactions with appropriate host membrane or nuclear receptors ( Intestinal TJ proteins are involved in the regulation of barrier status which defines how the composition of the microbiota in the gut interacts with the immune cells

[DOI] [PubMed] [Google Scholar] 22.Tomasetti M., Alleva R., Borghi B., Collins A.R

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So, for an orally administered drug, the bioavailable fraction (F B ) is given by: Here F A is the fraction absorbed, F G the fraction remaining after metabolism in the gut mucosa and F H the fraction remaining after hepatic metabolism

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