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10.1016/J.CELL.2022.04.002 Cell

The phosphorylated enzyme is also less responsive to activation by fructose 1,6-bisphosphate and more sensitive to inhibition by alanine and ATP

Nevertheless, studies report that administering GRF(1-29) with similar modification to CJC-1295 no DAC may be safe and well tolerated for periods of 16 weeks [17]

Although early results are promising, they must be interpreted with balance, as future findings may reveal limitations in its efficacy

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McGowan, Charles R