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Outbreak of post-parturient infectious pustular vulvovaginitis in a New Zealand dairy herd

provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]

The data herein suggests that GPx1 deficiency could underlie the increased susceptibility of macrophages from patients with active CD for increased H 2 O 2 -cytotixicity

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