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Another class of compounds, which bind to the N-terminal domain (NTD) of AR and disrupt its interactions (AR-NTD inhibitors) may be especially relevant to interfere with cell-type specific mediators of AR function 197

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

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These results suggest that GBH-1(D72G) retains significant normal enzymatic function in worms, despite the high conservation of residue D72G

Understudied proteins: opportunities and challenges for functional proteomics