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6.1.2 Gut-derived factors Intestinal I/R injury leads to the leakage of gut-derived factors such as bacterial endotoxins (lipopolysaccharide, LPS), metabolites, and cytokines into the bloodstream (Nie et al., 2024)

European Journal of Pharmacology 794: 173-183.Google Scholar LU, Y., ZHANG, C., BUCHELI, P

Glu, glutamate

5.2 Cellular crosstalk Intestinal epithelial cells (IECs) constitute a critical physical barrier that segregates the intestinal lumen, with its diverse contents, including digested nutrients, commensal microbiota, and potential pathogens, from the underlying mucosal immune system (164)

10.1186/1471-230X-9-95 BMC Gastroenterol

However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71