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The lack of significant demyelination observed with 3 weeks administration of cuprizone powder may reflect delayed cuprizone intake, rather than a complete lack of efficacy, given the significant loss of mature ASPA+ oligodendrocytes seen in this group

Assogbadjo AE, Chadare FJ, Manda L, Sinsin B

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And, they can walk extended distances with the addition of cane or something to lean on

An alternative strategy of starting the diagnostic investigation with mRNA sequencing has also been recommended, particularly because of the delay in diagnosis that can occur when glutathione synthetase deficiency results from a splice site mutation (02)

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