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Likewise, loss of IGF1 signal reduces the expression of mitochondrial biogenesis markers ( PGC1 , TFAM ) in the steroidogenic cells of prepubertal testis (Radovic et al., 2019)

Indeed, contradictory findings suggest that excess Cu 2+ may induce cell death via apoptosis, 249 caspase-independent cell death, or an accumulation of ROS

PMID: 17369935 Sudakov KV, Umriukhin PE, Rayevsky KS

In their review of the evidence, FDA scientists flag potential safety concerns and a lack of consistent data

Comparative analysis showed that D-CuP exhibited higher binding affinities than its monomeric counterpart M-CuP, with Vina scores of -5.7 kcal/mol for p53 and -6.4 kcal/mol for HDAC7, compared to -4.2 kcal/mol and -4.8 kcal/mol for M-CuP, respectively (Fig