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In: Genetic toxicology of environmental chemicals - Part B: Genetic effects and applied mutagenesis

Gastroenterology 20 (47), 1775617772

The historical perspective Initial clinical findings that the intestinal epithelium of IBD patients is more permeable to tracer molecules known to permeate through the paracellular space 28, 29, 30, 31 led to the hypothesis that an uncontrolled mucosal barrier may help promote IBD pathogenesis

Combined with the immunological tolerance required for foetal acceptance, pregnancy creates a biological window of elevated Candida vulnerability, particularly in the third trimester