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Notably, nearly half are processed by CYP3A4 and CYP3A5 specifically, with another quarter handled by CYP2C8 or CYP2C9 Conversely, drugs containing a carboxylic acid functional group may pose a lower risk of DILI, as they are typically metabolized to acyl glucuronides that are readily excreted ( Fig

Eng 2017, 11, 663675

SuberoylAnilide Hydroxamic Acid (SAHA) is a well-known inhibitor of histone deacetylase activity but it triggers neoplastic cell re-differentiation and cytostasis rather than tumour size reduction, thus limiting the use of standard imaging techniques

Popoek LL, Kraevec N, Bajc G, Glava U, Hrovatin M, Perko , Skoaj M (2024) New insights into interactions between mushroom aegerolysins and membrane lipids

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