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10.1016/j.biochi.2011.09.008 6 AlvarezM

10.1152/physrev.00058.2021 43 HeW.TangY.LiC.ZhangX.HuangS.TanB.et al (2021)

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells

The surface symptoms interact with one another and look like a symptom that appears to be completely different

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Gastrointestinal symptoms including nausea, vomiting, diarrhea, constipation, and abdominal discomfortare the most frequently reported adverse effects, occurring in 20-30% of patients (varying by dose and population), particularly during dose escalation