bacterial and host-derived glutathione are required to activate prfa Allosteric GSH binding primes for DNA binding. (A B) Multiple regulatory check-points control prfA

Multiple regulatory check points control prfA expression and protein Download Scientific Diagram Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion mBio Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis PLOS Pathogens RCSB PDB 5LRS: The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with glutathione and a 30 bp operator PrfA box motif Structural basis of promiscuous inhibition of Listeria virulence activator PrfA by oligopeptides: Cell Reports Diverse roles of low molecular weight thiol GSH in Francisella's virulence, location sensing and GSH stealing from host ScienceDirect

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