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In particular, the integration of stable isotope tracing and MSI has proven to be highly beneficial for investigating metabolic activity in heterogeneous tissues 12 and spatially mapping the flux of fatty acid synthesis and elongation in gliomas and healthy brain tissue 13

Finally, inflammation and endothelial activation leads to a pro-thrombotic phenotype due to the upregulation of components of the coagulation cascade including tissue factor (TF) (Sohn et al., 2005)

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Because reactive oxygen species (ROS) play key regulatory roles in multiple redox-sensitive signaling cascades, maintaining their concentrations within a physiological range is essential for cellular homeostasis

Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR